PRESS RELEASE

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4Life® Transfer Factor™ Now Approved By the Health Ministry of
Russia for use in Hospitals and Clinics!

First Ever Dietary Supplement to be Approved/or Use by Doctors and Hospitals in Russia

SANDY, UT (October 1, 2004) - In an unprecedented announcement in the history of network marketing, 4Life announced today that 4Life Transfer Factor products as immune modulators have been approved for use in hospitals and clinics in the Russian Federation. The results of ten separate clinical trials and two experimental studies on 4Life Transfer Factor products were combined in a Methodological Document that was approved by the Ministry of Health, which now allows doctors to recommend 4Life Transfer Factor Classic and 4Life Transfer Factor Plus® products to their patients.

First Dietary Supplement Approved for Use by Doctors and Hospitals in Russia

Commenting on this remarkable achievement, David Lisonbee, CEO of 4Life stated, "To my knowledge. this is the first time in the history of this industry that a network marketing company or any other dietary supplement company has had one of its dietary supplements approved for use in hospitals in Russia. The Russian Ministry of Health is the equivalent of the Food and Drug Administration in the United States. Doctors and scientists from Russia have been working jointly with scientists from 4Life for several years to arrive at this accomplishment. This approval establishes a new roll of dietary supplements in the Russian health care system.

Remarkable Response from Russian Academy of Medical Sciences

In another sector of research of 4Life Transfer Factor, Dr. Kisielevsky of the Russian Academy of Medical Sciences stated, "The 4Life sample [Transfer Factor Advanced Formula] activated NK (natural killer) cell activity more than the Interleukin-2 (IL2) drug we used as the standard," This discovery has attracted the attention of The International Scientific and Technical Center (ISTC) of Russia.Scientists from Several Countries Join Forces for Additional Clinical Studies of Transfer Factor

The ISTC of Russia is a member of a joint international project with other health agencies of Japan, Europe and the US, The objective of the international project is to combine efforts in finding improved immunotherapies. Following the discoveries from the NK cell testing, the scientists of 4Life have been invited to join the project. 4Life Transfer Factor as an immune modulator will be farther researched in this international forum. The cost of the studies will be paid by the ISTC.

Worldwide Ramification

Speaking of this benchmark achievement, Dr. Calvin McCausland. VP of Research of 4Life, and Dr. Emma Oganova, 4Life Eurasia President, jointly expressed that because of the acceptance by such a reputable organization and doctors from Russia and other major countries, 4Life Transfer Factor will gain wider acceptance in the professional and private sectors as a superior immune system enhancing product. The worldwide ramifications to this acceptance are just beginning.

KILL OR BE KILLED

NK CELLS ARE YOUR FIRST AND LAST LINE OF DEFENSE

Natural Killer (NK) Cells are a type of lethal lymphocyte

Scientists estimate that NK cells make up five to 15 percent of the total number of white blood cells that the body uses to fight infections. Those with defective or absent NK cell activity can contract a wide specturm of diseases, particularly cancers. Results from a number of clinical trials indicate that NK cells can be used to control tumor metastates. The therapeutic uses of NK cell activity will likely increase as their relationships to healthy and diseased cells becomes better known.

 

Natural Killer (NK) cells - NK cells were discovered in the 1970's and are a subset of large granular lymphocytes that are cytotoxic cells. They are called "natural" killers because they, unlike cytotoxic T cells, do not need to recognize a specific antigen before swinging into action. They are capable of spontaneously killing tumor or virus-infected cells. In several immuno-deficiency diseases, including AIDS, natural killer cell function is abnormal. Natural killer cells may also contribute to immuno-regulation by secreting high levels of influential lymphokines.

Natural Killer (NK) cells have no immunological memory and are independent of the adaptive immune system, NK cells make up approximately 15% of the human white blood cells. Their specific function is to kill infected and cancerous cells.

Recent research reveals that NK cells are involved in multiple effector, regulatory and developmental activities of the immune system. Research has confirmed that low NK cell activity causes one to be more susceptible to autoimmune diseases such as CFS, viral infections and the development of cancer cells.

Any statement that natural killer (NK) cells play an "important role" in human health is as casual as saying that the brain is important for bodily function. If our brain is not present and active we cannot continue "living". If our immune system is not armed and working well we will also not continue "living" for very long. NK cell activity is to the immune system, what brain activity is to the body.

 

Activated NK cells produce a variety of cytokines, including interferons, interlukins, TNF (Tumor Necrosis Factor, hematopietic cell growth factors and other growth factors. There is substantial evidence that indicates the involvement of NK cells in the interactions of the immune system with the neuroendocrine axis. They also appear to be responsible for activities at the interface between the immune system and the reproductive and neurological systems.

NK cell activity and NK cell count are not the same. NK cells may be present in sufficient numbers, but unless they are activated they are ineffective in doing their job. Decreased NK cell activity is linked to the development and progression of many diseases. According to the Center of Disease Control, low NK cell activity is present in all illness. NK cell function appears to be a biologic marker for disease and is an important indicator for declining or improving health.

The following assertion can be made; if one is suffering from an illness, be it chronic, recurring or acute, the NK cell activity would be below normal. The restoration of NK cell activity to a high normal would be desirable, if not necessary, for recovery.

Low NK cell activity begins with stress of some type. When the body is unable to adequately adapt to the environment there is a resulting compromise of body function. Stress comes through loss of sleep, overwork, emotional encounters, lack of exercise, poor nutrition, exposure to toxins, exposure to germs etc.

Excessive stress causes many detrimental changes in the body physiology and particularly the immune system. There is research evidence that there is a relationship between Natural Killer (NK) cell activity and reaction to emotional stress. There is low NK cell activity in individuals who have difficulty in handing stress and those suffering from behavioral disorders.

Acute low NK cell activity resulting from temporary stress can be eliminated with the elimination of the stress factor. For example, if we are over-tired and under-nourished we can simply rest and eat properly for a few days and recover. However when we become continually immune compromised we start developing recurring problems which may lead into serious or chronic conditions.

 

NK cell activity level is lowered in times of stress and can become chronically low with chronic stress. Research shows that normal NK cell activity is essential to the recovery and maintenance of good health. One way to offset the effects of stress is to normalize NK cell function.

When the immune system is overwhelmed the communication pathways are compromised and remain compromised until re-established. If the communication networks are not restored there is little opportunity for the immune system to regain full defensive capability.

 

Communication in the immune system, is accomplished through the cytokine mechanism. These messenger molecules must be activated to energize the communication capability that is necessary for immune system reliability.

 

Conversely, immune modulation that harnesses the body's ability to regulate will have an all-encompassing immune response that is not limited to one specific area of immune response. Regulation, upward or downward, in accordance with the needs of the body will be achieved.

 

 

TRANSFER ACTOR, THE ULTIMATE IMMUNE SYSTEM MODULATOR

Independent study results show transfer factors ability to increase

NK Cell activity by 437% over baseline!

 

Our bodies have a natural defense against cancer in the form on NK, (Natural Killer) cells. They circulate through our body, seeking cells that have unusual molecules on their surface which indicate that the cell is either a tumor cell or it is infected with a virus.

When such a cell is found, the NK cell opens up and extends a tentacle to the ailing cell and engages the "Killer Activating Receptor" in preparation to destroy the cell. Another tentacle reaches out to seek another spot in the cell, the "Killer Inhibitory Receptor". If this spot is not found, the NK cell blasts the sick cell with particles that punch holes in the bad cell wall and pumps venom into it that surges in and out of the cell until it explodes into bits.

This sounds like science fiction, but this event is enacted 10,000 times a day in a healthy person's body as tumor cells are routinely destroyed when they are formed.

The destruction of the tumor cells leaves evidence in the blood serum which can be measured by means of the AMAS test. Since this cell destruction is normal, the evidence is always present in a healthy person's body. High readings of the residue (Tag 1 and Tag 2 of the AMAS test. Call 1-800-9CATEST to receive information and a free test kit) indicate that a lot of tumor killing activity is occurring in the body and further tests should be done to determine the cause.
 

Rockefeller University Study

Natural killer cells are made, not born
First evidence of immune cell's activation potential in infection, tumor control

Call it the immune system's version of nature versus nurture.

For years, scientists regarded natural killer cells as a blunt instrument of the body's immune defense system. Born to kill, these cells were thought to travel straight from the bone marrow, where they are manufactured, to the blood, circulating there and infiltrating the sites of early tumors or infectious agents in the body.

Now, Rockefeller University scientists, led by Christian Münz, Ph.D., have learned otherwise. Natural killer cells, Münz and his colleagues say, have to be nurtured. Their ability to destroy tumor and infected cells is not present at birth.

This new insight paves the road to changes in bone marrow and stem cell transplant procedures and will enable scientists to pursue research into activating natural killer cells to help the body fight emerging infections and tumors.

In two separate papers in the February issue of The Journal of Immunology, Münz, postdoctoral associate Guido Ferlazzo, Ph.D., and their colleagues show that natural killer cells accumulate mostly in "secondary lymphoid tissues" - the tonsils, lymph nodes and spleen - after emerging from the bone marrow. There, the natural killer cells await activation (probably after stimulation by sentinel dendritic cells) before they react in two distinct modes. In one mode, they promptly secrete cytokines, chemical messenger proteins, which modulate emerging T and B immune cell responses. In the other, they become potent killers of tumors and virus-infected cells. While natural killer cells do provide a crucial first defense against many infectious agents and tumor cells, they do so with more discrimination than raw determination.

"Natural killer cells burst forth from the the tonsils, lymph nodes and spleen, and destroy infected and cancerous cells while the immune system's T and B cells are still mobilizing," says Münz. "Without natural killer cells, threatening conditions can get a strong foothold before the adaptive immune response kicks in."

Leading oncologists treating human leukemias and lymphomas already track natural killer cell activities after bone marrow and stem cell transplants. James Young, M.D., a researcher at Rockefeller's neighboring Memorial Sloan-Kettering Cancer Center's Allogenic Bone Marrow and Stem Cell Transplant Service, is one of them. "The emerging data on the activation of natural killer cells, their distinct functions in the body and their cellular targets, are helping to move the study of natural killer cells in transplantation and cancer from conjecture to sound hypotheses," he says.

4Life is the world's foremost leader in the development, production and distribution of natural immune support products and was recently recognized by Inc. magazine as the fifteenth fastest growing privately-held company in America.